Synthesis and evaluation of (bis)benzyltetrahydroisoquinoline alkaloids as antiparasitic agents

Visceral leishmaniasis and Chagas disease are neglected tropical diseases (NTDs) that severely impact the developing world. With current therapies suffering from poor efficacy and safety profiles as well as emerging resistance, new drug leads are direly needed. In this work, 26 alkaloids (9 natural...

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Bibliographic Details
Main Authors: Sozanschi, A, Asiki, H, Amaral, M, de Castro Levatti, EV, Tempone, AG, Wheeler, RJ, Anderson, EA
Format: Journal article
Language:English
Published: American Chemical Society 2024