Selection for beta 2-microglobulin mutation in mismatch repair-defective colorectal carcinomas.

Selection for beta 2-microglobulin mutation in mismatch repair-defective colorectal carcinomas.

Novel peptide antigens complexed with human leukocyte antigen (HLA) and beta 2-microglobulin (beta 2M) molecules are presented at the cell surface to cytotoxic T lymphocytes (CTLs), provoking lysis of the antigen-presenting cell [1]. In tumor cells, genetically altered or abnormally expressed protei...

Полное описание

Библиографические подробности
Главные авторы:	Bicknell, D, Kaklamanis, L, Hampson, R, Bodmer, W, Karran, P
Формат:	Journal article
Язык:	English
Опубликовано:	1996

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