Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?

Folates have a key role in metabolism, and the folate-dependent generation of DNA precursors in the form of deoxythymidine 5'-phosphate is particularly important for the replication of malaria parasites. Although Plasmodium falciparum can synthesize folate derivatives de novo, a long-standing m...

Full description

Bibliographic Details
Main Authors: Hyde, J, Dittrich, S, Wang, P, Sims, P, de Crécy-Lagard, V, Hanson, A
Format: Journal article
Language:English
Published: 2008