Investigating the role of ADAM10 and ADAM17 in cetuximab resistance in head and neck squamous cell carcinoma

<p>Epithermal Growth Factor Receptor (EGFR) is overexpressed in up to 90% of head and neck squamous cell carcinoma (HNSCC). Cetuximab is the first and the only anti-EGFR monoclonal antibody which received approval from FDA for the treatment of HNSCC. However, most patients either do not respon...

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Bibliographic Details
Main Author: Kareemaghay, S
Other Authors: Seymour, L
Format: Thesis
Language:English
Published: 2014
Subjects: