On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage.
The p53 gene is required for the normal apoptotic response of mammalian cells to DNA damage caused by ionizing radiation and DNA damaging drugs. DNA damage results in the accumulation of biologically active p53. This response is potentially lethal and is therefore highly regulated. By using both bio...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1995
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