Endothelial cell tetrahydrobiopterin modulates sensitivity to Ang (Angiotensin) II–induced vascular remodeling, blood pressure, and abdominal aortic aneurysm

GTP cyclohydrolase 1 (GTPCH, encoded by Gch1) is required for the synthesis of tetrahydrobiopterin (BH4); a critical regulator of endothelial NOS (eNOS) function. We have previously shown that mice with selective loss of Gch1 in endothelial cells have mild vascular dysfunction, but the consequences...

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Váldodahkkit: Chuaiphichai, S, Rashbrook, V, Hale, A, Trelfa, L, Patel, J, McNeill, E, Lygate, C, Channon, K, Douglas, G
Materiálatiipa: Journal article
Almmustuhtton: American Heart Association 2018