Endothelial cell tetrahydrobiopterin modulates sensitivity to Ang (Angiotensin) II–induced vascular remodeling, blood pressure, and abdominal aortic aneurysm
GTP cyclohydrolase 1 (GTPCH, encoded by Gch1) is required for the synthesis of tetrahydrobiopterin (BH4); a critical regulator of endothelial NOS (eNOS) function. We have previously shown that mice with selective loss of Gch1 in endothelial cells have mild vascular dysfunction, but the consequences...
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Journal article |
| Έκδοση: |
American Heart Association
2018
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