Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding.

S-1153 (AG1549) is perhaps the most promising non-nucleoside inhibitor of HIV-1 reverse transcriptase currently under development as a potential anti-AIDS drug, because it has a favorable profile of resilience to many drug resistance mutations. We have determined the crystal structure of S-1153 in a...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Ren, J, Nichols, C, Bird, L, Fujiwara, T, Sugimoto, H, Stuart, D, Stammers, D
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2000