Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.

OBJECTIVE: To investigate the role of the transcription factor nuclear factor-kB (NF-kappaB) in promoting inflammatory and destructive responses in human osteoarthritis (OA) synovial fibroblasts, by assessing the effect of NF-kappaB blockade on the production of cytokines and destructive enzymes. M...

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Bibliographic Details
Main Authors: Bondeson, J, Lauder, S, Wainwright, S, Amos, N, Evans, A, Hughes, C, Feldmann, M, Caterson, B
Format: Journal article
Language:English
Published: 2007