On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

The role of peroxisome proliferator-activated receptora(PPARa)-mediated metabolic remodeling in cardiac adaptation to hypoxia has yet to be defined. Here, mice were housed in hypoxia for 3 wk beforein vivocontractile function was measured using cine MRI. In isolated, perfused hearts, energetics were...

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Bibliographic Details
Main Authors:	Cole, M, Jamil, A, Heather, L, Murray, A, Sutton, E, Slingo, M, Sebag-Montefiore, L, Tan, S, Aksentijevic, D, Gildea, O, Stuckey, D, Yeoh, K, Carr, C, Evans, R, Aasum, E, Schofield, C, Ratcliffe, P, Neubauer, S, Robbins, P, Clarke, K
Format:	Journal article
Published:	Federation of American Society of Experimental Biology 2016

On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

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