Computationally profiling peptide: MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies

<p>T-cell receptor-mimetic antibodies (TCRms) targeting disease-associated peptides presented by Major Histocompatibility Complexes (pMHCs) are set to become a major new drug modality. However, we lack a general understanding of how TCRms engage pMHC targets, which is crucial for predicting th...

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Bibliographic Details
Main Authors: Raybould, MIJ, Nissley, DA, Kumar, S, Deane, CM
Format: Journal article
Language:English
Published: Frontiers Media 2023