Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis

Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis

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Manylion Llyfryddiaeth
Prif Awduron:	Milne, T, Kim, J, Wang, G, Stadler, S, Basrur, V, Whitcomb, S, Wang, Z, Ruthenburg, A, Elenitoba-Johnson, K, Roeder, R, Allis, C
Fformat:	Journal article
Cyhoeddwyd:	2010

Eitemau Tebyg

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.
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Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
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The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis
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MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia
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Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C
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An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
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Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens
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Dimerization of MLL fusion proteins immortalizes hematopoietic cells.
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Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis
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Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia.
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MLL targets SET domain methyltransferase activity to Hox gene promoters.
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The MLL family of proteins in normal development and disease
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MLL associates specifically with a subset of transcriptionally active target genes.
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Genome-wide analyses reveal new insights into MLL fusion protein recruitment mechanisms
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Research progress in Menin-MLL interaction and its inhibitors in MLL-rearranged leukemia
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Histone H3K36me2-Specific Methyltransferase ASH1L Promotes MLL-AF9-Induced Leukemogenesis
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Molecular characterization of an MLL1 fusion and its role in chromosomal instability
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Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
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Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications.
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Cyhoeddwyd: (2005)

Correction: Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
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MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer
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RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.
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Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival
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