Structural biology of IgG Fc glycoforms
The conserved N-linked glycosylation site on the Fc domain of IgG1 antibodies is essential for maintaining a functionally active conformation of the antibody. Different glycoforms of the Fc exhibit widely different effector functions. Similarly, therapeutic antibodies, with engineered glycosylatio...
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| Format: | Thesis |
| Language: | English |
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2012
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