A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

Chronic hepatitis B is one of the world's unconquered diseases with more than 240 million infected subjects at risk of developing liver disease and hepatocellular carcinoma. Hepatitis B virus reverse transcribes pre-genomic RNA to relaxed circular DNA (rcDNA) that comprises the infectious parti...

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Detalhes bibliográficos
Main Authors: Wing, P, Davenne, T, Wettengel, J, Lai, A, Zhuang, X, Chakraborty, A, D'Arienzo, V, Kramer, C, Ko, C, Harris, J, Schreiner, S, Higgs, M, Roessler, S, Parish, J, Protzer, U, Balfe, P, Rehwinkel, J, McKeating, J
Formato: Journal article
Idioma:English
Publicado em: Life Science Alliance 2019