Genetic variants in ERAP1 and ERAP2 associated with immune-mediated diseases influence protein expression and the isoform profile

<h4>Objective</h4> <p>Endoplasmic reticulum aminopeptidase 1 (ERAP‐1) and ERAP‐2, encoded on chromosome 5q15, trim endogenous peptides for HLA‐mediated presentation to the immune system. Polymorphisms in ERAP1 and/or ERAP2 are strongly associated with several immune‐mediated disea...

全面介紹

書目詳細資料
Main Authors: Hanson, A, Cuddihy, T, Haynes, K, Loo, D, Morton, C, Oppermann, U, Leo, P, Thomas, G, Lê Cao, K, Kenna, T, Brown, M
格式: Journal article
語言:English
出版: Wiley 2017