Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease

Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease

A series of iminosugars bearing two or three alkyl chains ('iminoglycolipids') were designed as ceramide mimics and analogues of N-butyl 1-deoxynojirimycin (N-Bu DNJ, Zavesca®). This orally active iminosugar inhibits the biosynthesis of glucosylceramides, which accumulate pathologically in...

Полное описание

Библиографические подробности
Главные авторы:	Boucheron, C, Desvergnes, V, Compain, P, Martin, O, Lavi, A, Mackeen, M, Wormald, M, Dwek, R, Butters, T
Формат:	Journal article
Язык:	English
Опубликовано:	2005

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