Measurement of myofilament-localised calcium dynamics in adult cardiomyocytes and the effect of hypertrophic cardiomyopathy mutations

<p><strong>Rationale:</strong> Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mutation, or small molecules may alter contractility through myofilament Ca2+ sensitivity. Here we develop and characterise genetically encoded Ca2+ indicators rest...

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Bibliographic Details
Main Authors: Sparrow, A, Sievert, K, Patel, S, Chang, Y, Broyles, C, Brook, F, Watkins, H, Geeves, M, Redwood, C, Robinson, P, Daniels, M
Format: Journal article
Language:English
Published: American Heart Association 2019