Protein modulation of ion channels

Protein modulation of ion channels

Ion channels lie at the heart of electrical excitability. They represent attractive targets for treatments of a range of pathophysiological conditions, including pain, ischemia and epilepsy. To date, small molecule approaches have dominated ion channel drug discovery, but small molecules often lack...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Cloake, AM
Awduron Eraill:	Tucker, S
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2021
Pynciau:	Neurosciences Biochemistry Biophysics

Eitemau Tebyg

High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale
gan: Clemens Schulte, et al.
Cyhoeddwyd: (2021-01-01)

Molecular simulations of ion channel gating
gan: Pipatpolkai, T
Cyhoeddwyd: (2021)

Ion channels: structure of a molecular brake
gan: Sansom, M
Cyhoeddwyd: (1999)

Ion channels: a first view of K⁺ channels in atomic glory
gan: Sansom, M
Cyhoeddwyd: (1998)

Structural studies of a membrane embedded chloride channel from E.Coli, a prokaryotic homologue of ClC channels
gan: Bowler, M, et al.
Cyhoeddwyd: (2001)

Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor
gan: Smith, G, et al.
Cyhoeddwyd: (1997)

Metabolite and protein shifts in mature erythrocyte under hypoxia
gan: Xu Jin, et al.
Cyhoeddwyd: (2024-04-01)

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues
gan: Labro, A, et al.
Cyhoeddwyd: (2008)

Biophysical studies of membrane protein structure and function
gan: Dijkman, P, et al.
Cyhoeddwyd: (2014)

Biophysical and magnetic resonance studies of membrane proteins
gan: Orwick, M, et al.
Cyhoeddwyd: (2011)

The influence of environment: simulations of the influenza BM2 proton channel
gan: Rouse, S
Cyhoeddwyd: (2012)

Raw data for "Hundt et al., Direct observation of the molecular mechnism underlying protein polymerization, Science Advances 2022"
gan: Hundt, N, et al.
Cyhoeddwyd: (2022)

Radiation damage in protein crystals examined under various conditions by different methods
gan: Garman, E, et al.
Cyhoeddwyd: (2009)

Structural, biochemical and computational studies of TRP channel transmembrane domain modularity
gan: Hanson, S
Cyhoeddwyd: (2014)

Pushing the boundaries: molecular dynamics simulations of complex biological membranes
gan: Parton, D
Cyhoeddwyd: (2011)

Single molecule studies of a voltage-gated potassium channel
gan: Angué, L
Cyhoeddwyd: (2013)

Structural studies of malaria proteins
gan: Mayer, C
Cyhoeddwyd: (2012)

Hydrophobic gating and functional annotation of ion channels
gan: Klesse, G
Cyhoeddwyd: (2019)

K+ channels: gating mechanisms and lipid interactions
gan: Schmidt, M
Cyhoeddwyd: (2013)

Structural, biophysical and cellular analysis of synaptic receptors and organizers
gan: Clayton, AJ
Cyhoeddwyd: (2013)

Protocol for evaluating drug-protein interactions based on fluorescence spectroscopy
gan: Elaheh Jalali, et al.
Cyhoeddwyd: (2024-12-01)

A biophysical study of the G protein coupled receptor neurotensin receptor 1
gan: Harding, PJ
Cyhoeddwyd: (2007)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
gan: Marles-Wright, J
Cyhoeddwyd: (2005)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
gan: Marles-Wright, J
Cyhoeddwyd: (2005)

Optimising protein synthesis in cell‐free systems, a review
gan: Angelo C. Batista, et al.
Cyhoeddwyd: (2021-03-01)

Fluorescence studies of influenza RNA and RNA polymerase
gan: Tomescu, A
Cyhoeddwyd: (2014)

Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria
gan: Ng, HK
Cyhoeddwyd: (2012)

Allosteric contributions of muscle nicotinic acetylcholine receptor residues in small-molecule interactions, disease and subunit assembly
gan: Epstein, M
Cyhoeddwyd: (2019)

Investigating potential allostery in the transcription factor CREB
gan: Chung, NL
Cyhoeddwyd: (2020)

FEBS letters : for the rapid publication of short reports in biochemistry, biophysics and molecular biology
gan: Federation of European Biochemical Societies
Cyhoeddwyd: ([19-)

Journal of biochemical and biophysical methods
Cyhoeddwyd: (1975)

Biochemical and biophysical research communications
Cyhoeddwyd: (1959)

Journal of biochemical and biophysical methods [jurnal elektronik]

Autoinhibition of TRPV6 Channel and Regulation by PIP2
gan: Ruiqi Cai, et al.
Cyhoeddwyd: (2020-09-01)

The regulation and inhibition of P-TEFb
gan: Hole, A
Cyhoeddwyd: (2011)

Interactions of Neisseria meningitidis with the human immune system
gan: Harding, R
Cyhoeddwyd: (2015)

Determination of X-ray flux using silicon pin diodes
gan: Owen, R, et al.
Cyhoeddwyd: (2009)

Adapting nanobody scaffolds as protein chaperones for effective crystallization and good protein behaviour in cryo-EM
gan: Ye, M
Cyhoeddwyd: (2021)

Mass Photometry of Membrane Proteins
gan: Olerinyova, A, et al.
Cyhoeddwyd: (2020)

Studying marcomolecular transitions by NMR and computer simulations
gan: Stelzl, LS
Cyhoeddwyd: (2014)