Protein modulation of ion channels

Protein modulation of ion channels

Ion channels lie at the heart of electrical excitability. They represent attractive targets for treatments of a range of pathophysiological conditions, including pain, ischemia and epilepsy. To date, small molecule approaches have dominated ion channel drug discovery, but small molecules often lack...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Cloake, AM
Rannpháirtithe:	Tucker, S
Formáid:	Tráchtas
Teanga:	English
Foilsithe / Cruthaithe:	2021
Ábhair:	Neurosciences Biochemistry Biophysics

Míreanna comhchosúla

High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale
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Foilsithe / Cruthaithe: (2021-01-01)

Molecular simulations of ion channel gating
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Foilsithe / Cruthaithe: (2021)

Ion channels: structure of a molecular brake
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Foilsithe / Cruthaithe: (1999)

Ion channels: a first view of K⁺ channels in atomic glory
de réir: Sansom, M
Foilsithe / Cruthaithe: (1998)

Structural studies of a membrane embedded chloride channel from E.Coli, a prokaryotic homologue of ClC channels
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Foilsithe / Cruthaithe: (2001)

Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor
de réir: Smith, G, et al.
Foilsithe / Cruthaithe: (1997)

Metabolite and protein shifts in mature erythrocyte under hypoxia
de réir: Xu Jin, et al.
Foilsithe / Cruthaithe: (2024-04-01)

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues
de réir: Labro, A, et al.
Foilsithe / Cruthaithe: (2008)

Biophysical studies of membrane protein structure and function
de réir: Dijkman, P, et al.
Foilsithe / Cruthaithe: (2014)

Biophysical and magnetic resonance studies of membrane proteins
de réir: Orwick, M, et al.
Foilsithe / Cruthaithe: (2011)

The influence of environment: simulations of the influenza BM2 proton channel
de réir: Rouse, S
Foilsithe / Cruthaithe: (2012)

Raw data for "Hundt et al., Direct observation of the molecular mechnism underlying protein polymerization, Science Advances 2022"
de réir: Hundt, N, et al.
Foilsithe / Cruthaithe: (2022)

Radiation damage in protein crystals examined under various conditions by different methods
de réir: Garman, E, et al.
Foilsithe / Cruthaithe: (2009)

Structural, biochemical and computational studies of TRP channel transmembrane domain modularity
de réir: Hanson, S
Foilsithe / Cruthaithe: (2014)

Pushing the boundaries: molecular dynamics simulations of complex biological membranes
de réir: Parton, D
Foilsithe / Cruthaithe: (2011)

Single molecule studies of a voltage-gated potassium channel
de réir: Angué, L
Foilsithe / Cruthaithe: (2013)

Structural studies of malaria proteins
de réir: Mayer, C
Foilsithe / Cruthaithe: (2012)

Hydrophobic gating and functional annotation of ion channels
de réir: Klesse, G
Foilsithe / Cruthaithe: (2019)

K+ channels: gating mechanisms and lipid interactions
de réir: Schmidt, M
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Structural, biophysical and cellular analysis of synaptic receptors and organizers
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Protocol for evaluating drug-protein interactions based on fluorescence spectroscopy
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Foilsithe / Cruthaithe: (2024-12-01)

A biophysical study of the G protein coupled receptor neurotensin receptor 1
de réir: Harding, PJ
Foilsithe / Cruthaithe: (2007)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
de réir: Marles-Wright, J
Foilsithe / Cruthaithe: (2005)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
de réir: Marles-Wright, J
Foilsithe / Cruthaithe: (2005)

Optimising protein synthesis in cell‐free systems, a review
de réir: Angelo C. Batista, et al.
Foilsithe / Cruthaithe: (2021-03-01)

Fluorescence studies of influenza RNA and RNA polymerase
de réir: Tomescu, A
Foilsithe / Cruthaithe: (2014)

Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria
de réir: Ng, HK
Foilsithe / Cruthaithe: (2012)

Allosteric contributions of muscle nicotinic acetylcholine receptor residues in small-molecule interactions, disease and subunit assembly
de réir: Epstein, M
Foilsithe / Cruthaithe: (2019)

Investigating potential allostery in the transcription factor CREB
de réir: Chung, NL
Foilsithe / Cruthaithe: (2020)

FEBS letters : for the rapid publication of short reports in biochemistry, biophysics and molecular biology
de réir: Federation of European Biochemical Societies
Foilsithe / Cruthaithe: ([19-)

Journal of biochemical and biophysical methods
Foilsithe / Cruthaithe: (1975)

Biochemical and biophysical research communications
Foilsithe / Cruthaithe: (1959)

Journal of biochemical and biophysical methods [jurnal elektronik]

Autoinhibition of TRPV6 Channel and Regulation by PIP2
de réir: Ruiqi Cai, et al.
Foilsithe / Cruthaithe: (2020-09-01)

The regulation and inhibition of P-TEFb
de réir: Hole, A
Foilsithe / Cruthaithe: (2011)

Interactions of Neisseria meningitidis with the human immune system
de réir: Harding, R
Foilsithe / Cruthaithe: (2015)

Determination of X-ray flux using silicon pin diodes
de réir: Owen, R, et al.
Foilsithe / Cruthaithe: (2009)

Adapting nanobody scaffolds as protein chaperones for effective crystallization and good protein behaviour in cryo-EM
de réir: Ye, M
Foilsithe / Cruthaithe: (2021)

Mass Photometry of Membrane Proteins
de réir: Olerinyova, A, et al.
Foilsithe / Cruthaithe: (2020)

Studying marcomolecular transitions by NMR and computer simulations
de réir: Stelzl, LS
Foilsithe / Cruthaithe: (2014)