Running out of time: the decline of channel activity and nucleotide activation in ATP-sensitive K-channels
KATP channels act as key regulators of electrical excitability by coupling metabolic cues - mainly intracellular adenine nucleotide concentrations - to cellular potassium ion efflux. However, their study has been hindered by their rapid loss of activity in excised membrane patches (rundown), and by...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
Royal Society
2016
|