Running out of time: the decline of channel activity and nucleotide activation in ATP-sensitive K-channels

Running out of time: the decline of channel activity and nucleotide activation in ATP-sensitive K-channels

KATP channels act as key regulators of electrical excitability by coupling metabolic cues - mainly intracellular adenine nucleotide concentrations - to cellular potassium ion efflux. However, their study has been hindered by their rapid loss of activity in excised membrane patches (rundown), and by...

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Bibliographic Details
Main Authors:	Proks, P, Puljung, M, Vedovato, N, Sachse, G, Mulvaney, R, Ashcroft, F
Format:	Journal article
Published:	Royal Society 2016

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