Running out of time: the decline of channel activity and nucleotide activation in ATP-sensitive K-channels

Running out of time: the decline of channel activity and nucleotide activation in ATP-sensitive K-channels

KATP channels act as key regulators of electrical excitability by coupling metabolic cues - mainly intracellular adenine nucleotide concentrations - to cellular potassium ion efflux. However, their study has been hindered by their rapid loss of activity in excised membrane patches (rundown), and by...

Podrobná bibliografie
Hlavní autoři:	Proks, P, Puljung, M, Vedovato, N, Sachse, G, Mulvaney, R, Ashcroft, F
Médium:	Journal article
Vydáno:	Royal Society 2016

Podobné jednotky

Correction to 'Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels'.
Autor: Proks, P, a další
Vydáno: (2016)

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding
Autor: Puljung, M, a další
Vydáno: (2019)

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding
Autor: Michael Puljung, a další
Vydáno: (2019-02-01)

Visualizing adenine nucleotide regulation of the K-ATP channel
Autor: Usher, SG, a další
Vydáno: (2018)

Differential metabolic and nucleotide sensitivity of beta-cell and cardiac K-ATP channels
Autor: Vedovato, N, a další
Vydáno: (2018)

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry
Autor: Usher, SG, a další
Vydáno: (2020)

Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.
Autor: Proks, P, a další
Vydáno: (2010)

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry
Autor: Samuel G Usher, a další
Vydáno: (2020-01-01)

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.
Autor: Trapp, S, a další
Vydáno: (1998)

Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus.
Autor: Mikhailov, M, a další
Vydáno: (1998)

Gating and ATP-sensitivity of the cloned beta-cell K-ATP channel
Autor: Trapp, S, a další
Vydáno: (1998)

How ATP inhibits the open K(ATP) channel.
Autor: Craig, T, a další
Vydáno: (2008)

Regulation of K-ATP channels by nucleotides and drugs
Autor: Gribble, F, a další
Vydáno: (2000)

Modeling K(ATP) channel gating and its regulation.
Autor: Proks, P, a další
Vydáno: (2009)

Mechanism of K-ATP channel inhibition by ATP
Autor: Ashcroft, F, a další
Vydáno: (1998)

Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits.
Autor: Trapp, S, a další
Vydáno: (1997)

Dynamic sensitivity of K-ATP channels to ATP
Autor: Loussouarn, G, a další
Vydáno: (2001)

THE EFFECT OF INTRACELLULAR PROTONS ON ATP-SENSITIVE K+ CHANNELS IN MOUSE PANCREATIC BETA-CELLS
Autor: Proks, P, a další
Vydáno: (1993)

Inhibition of ATP-sensitive potassium channels by haloperidol.
Autor: Yang, S, a další
Vydáno: (2004)

Properties and functions of ATP-sensitive K-channels.
Autor: Ashcroft, S, a další
Vydáno: (1990)

Modification of K-ATP channels in pancreatic beta-cells by trypsin.
Autor: Proks, P, a další
Vydáno: (1993)

Dynamic sensitivity of ATP-sensitive K(+) channels to ATP.
Autor: Loussouarn, G, a další
Vydáno: (2001)

Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA.
Autor: Gribble, F, a další
Vydáno: (1998)

Phentolamine block of ATP-sensitive K+ channels does not involve interaction with the sulphonylurea receptor, SUR1.
Autor: Proks, P, a další
Vydáno: (1997)

Inhibition of cloned K-ATP channels by stilbene disulphonates
Autor: Proks, P, a další
Vydáno: (2000)

Interaction of stilbene disulphonates with cloned K(ATP) channels.
Autor: Proks, P, a další
Vydáno: (2001)

A model for regulation of the beta-cell ATP-sensitive K+-channel by nucleotides and diazoxide.
Autor: Tucker, S, a další
Vydáno: (1997)

Interaction of MgATP with the sulphonylurea subunit activates ATP sensitive K-channels receptor
Autor: Gribble, F, a další
Vydáno: (1998)

Interactions between tolbutamide and nucleotides on cloned K-ATP channels.
Autor: Gribble, F, a další
Vydáno: (1997)

Effects of intracellular pH on ATP-sensitive K+ channels in mouse pancreatic beta-cells.
Autor: Proks, P, a další
Vydáno: (1994)

THE EFFECT OF INTRACELLULAR PH ON ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS
Autor: Proks, P, a další
Vydáno: (1993)

Interaction of vanadate with the cloned beta cell K(ATP) channel.
Autor: Proks, P, a další
Vydáno: (1999)

Modulation of gating of the cloned beta-cell K-ATP channel
Autor: Proks, P, a další
Vydáno: (1998)

A touching case of channel regulation: the ATP-sensitive K+ channel.
Autor: Tucker, S, a další
Vydáno: (1998)

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.
Autor: Reimann, F, a další
Vydáno: (2003)

EFFECTS OF TRYPSIN ON ATP-DEPENDENT-K+ CHANNELS FROM PANCREATIC BETA-CELLS
Autor: Proks, P, a další
Vydáno: (1992)

Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.
Autor: Tanabe, K, a další
Vydáno: (1999)

Correlating structure and function in ATP-sensitive K+ channels.
Autor: Ashcroft, F, a další
Vydáno: (1998)

ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells.
Autor: Tarasov, A, a další
Vydáno: (2006)

THE EFFECT OF CHANGES IN INTRACELLULAR ATP CONCENTRATION ON THE ACTIVITIES OF ATP-SENSITIVE K-CHANNELS AND OF NA-K-ATPASE IN INTACT HIT-T15 B-CELLS
Autor: Niki, I, a další
Vydáno: (1989)