Targeting Plasmodium PI(4)K to eliminate malaria

Targeting Plasmodium PI(4)K to eliminate malaria

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Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH kinase (PI(4)K), as the target of imidazopyrazines, a new antimalarial compound class that inhibits the intracellular de...

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Bibliographic Details
Main Authors: McNamara, C, Lee, M, Lim, C, Lim, S, Roland, J, Nagle, A, Simon, O, Yeung, B, Chatterjee, A, McCormack, S, Manary, M, Zeeman, A, Dechering, K, Kumar, T, Henrich, P, Gagaring, K, Ibanez, M, Kato, N, Kuhen, K, Fischli, C, Rottmann, M, Plouffe, D, Bursulaya, B, Meister, S, Rameh, L
Format: Journal article
Language:English
Published: 2013

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