BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis.

AIMS: BNIP3 is a pro-apoptotic mitochondrial protein induced under hypoxic stress, with the BNIP3 gene being under direct regulation of the hypoxia-inducible HIF-1alpha transcription factor. Induction of BNIP3 leads to caspase-independent necrosis-like cell death and an aggressive tumour phenotype....

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Giatromanolaki, A, Koukourakis, M, Gatter, K, Harris, A, Sivridis, E
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2008