BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis.

BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis.

AIMS: BNIP3 is a pro-apoptotic mitochondrial protein induced under hypoxic stress, with the BNIP3 gene being under direct regulation of the hypoxia-inducible HIF-1alpha transcription factor. Induction of BNIP3 leads to caspase-independent necrosis-like cell death and an aggressive tumour phenotype....

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Bibliographic Details
Main Authors:	Giatromanolaki, A, Koukourakis, M, Gatter, K, Harris, A, Sivridis, E
Format:	Journal article
Language:	English
Published:	2008

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