Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.

Analogues of the naturally occurring cyclic hydroxamate dealanylalahopcin, which is an inhibitor of procollagen prolyl-4-hydroxylase, were synthesised and shown to be inhibitors of the human hypoxia-inducible factor prolyl hydroxylases.

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Schlemminger, I, Mole, D, McNeill, L, Dhanda, A, Hewitson, K, Tian, Y, Ratcliffe, P, Pugh, C, Schofield, C
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2003

Ижил төстэй зүйлс

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
-н: Mole, D, зэрэг
Хэвлэсэн: (2003)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
-н: McNeill, L, зэрэг
Хэвлэсэн: (2002)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
-н: Tuckerman, JR, зэрэг
Хэвлэсэн: (2004)

Regulation of HIF: prolyl hydroxylases.
-н: Stolze, I, зэрэг
Хэвлэсэн: (2006)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
-н: Chan, M, зэрэг
Хэвлэсэн: (2016)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
-н: Yeoh, K, зэрэг
Хэвлэсэн: (2013)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
-н: Yeh, TL, зэрэг
Хэвлэсэн: (2017)

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
-н: Tian, Y, зэрэг
Хэвлэсэн: (2006)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
-н: Chowdhury, R, зэрэг
Хэвлэсэн: (2016)

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
-н: Mecinović, J, зэрэг
Хэвлэсэн: (2009)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
-н: Hewitson, K, зэрэг
Хэвлэсэн: (2007)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
-н: Elkins, J, зэрэг
Хэвлэсэн: (2003)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
-н: Holt-Martyn, JP, зэрэг
Хэвлэсэн: (2019)

ENANTIOSPECIFIC SYNTHESIS OF DEALANYLALAHOPCIN
-н: Baldwin, J, зэрэг
Хэвлэсэн: (1990)

STEREOSPECIFIC SYNTHESIS OF DEALANYLALAHOPCIN
-н: Baldwin, J, зэрэг
Хэвлэсэн: (1990)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
-н: Cockman, M, зэрэг
Хэвлэсэн: (2019)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
-н: Conejo-Garcia, A, зэрэг
Хэвлэсэн: (2005)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
-н: Chowdhury, R, зэрэг
Хэвлэсэн: (2013)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
-н: Rasheduzzaman Chowdhury, зэрэг
Хэвлэсэн: (2016-08-01)

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
-н: Masson, N, зэрэг
Хэвлэсэн: (2004)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
-н: Hewitson, K, зэрэг
Хэвлэсэн: (2002)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
-н: Matthew E Cockman, зэрэг
Хэвлэсэн: (2019-09-01)

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
-н: Epstein, A, зэрэг
Хэвлэсэн: (2001)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
-н: Willam, C, зэрэг
Хэвлэсэн: (2006)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
-н: Masson, N, зэрэг
Хэвлэсэн: (2003)

Oxygen sensing by HIF hydroxylases.
-н: Schofield, C, зэрэг
Хэвлэсэн: (2004)

Signalling hypoxia by HIF hydroxylases.
-н: Schofield, C, зэрэг
Хэвлэсэн: (2005)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
-н: Andrey A. Poloznikov, зэрэг
Хэвлэсэн: (2021-01-01)

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging
-н: Mayer, M, зэрэг
Хэвлэсэн: (2018)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
-н: Takahiro Kambara, зэрэг
Хэвлэсэн: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
-н: Kiichi Hirota
Хэвлэсэн: (2021-04-01)

Iron homeostasis and its interaction with prolyl hydroxylases.
-н: Mole, D
Хэвлэсэн: (2010)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
-н: Singh, A, зэрэг
Хэвлэсэн: (2020)

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
-н: McNeill, L, зэрэг
Хэвлэсэн: (2005)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
-н: Chen, R, зэрэг
Хэвлэсэн: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
-н: Chen, R, зэрэг
Хэвлэсэн: (2014)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
-н: Flashman, E, зэрэг
Хэвлэсэн: (2010)

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
-н: Astuti, D, зэрэг
Хэвлэсэн: (2011)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
-н: Astuti, D, зэрэг
Хэвлэсэн: (2010)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
-н: Moritz J. Strowitzki, зэрэг
Хэвлэсэн: (2021-04-01)