Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining.

HLA class I tetramers have revolutionized the study of Ag-specific CD8+ T cell responses. Technical problems and the rarity of Ag-specific CD4+ Th cells have not allowed the potential of HLA class II tetramers to be fully realized. Here, we optimize HLA class II tetramer staining methods through the...

Полное описание

Библиографические подробности
Главные авторы: Scriba, T, Purbhoo, M, Day, C, Robinson, N, Fidler, S, Fox, J, Weber, J, Klenerman, P, Sewell, A, Phillips, R
Формат: Journal article
Язык:English
Опубликовано: 2005