The role(s) of hypoxia-inducible factors (HIFs) in the development of renal cysts in mice deficient in fumarate hydratase (Fh1)
Fumarate hydratase (FH) encodes a Krebs cycle (also called TCA cycle) enzyme which converts fumarate to malate and also functions as a tumour suppressor gene. Germline mutations in FH predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Affected individuals develop benign smooth mu...
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| Natura: | Tesi |
| Lingua: | English |
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2011
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