Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a D-glucotriazole carboxylate

Triazole-carboxylic acids related to D-glucose and D-galactose may be prepared by intramolecular [1,3]-dipolar cycloadditions of azides to unsaturated esters, followed by bromine oxidation of the resulting triazoline. Such materials may provide a series of anionic mimics of carbohydrates.

Detaylı Bibliyografya
Asıl Yazarlar: Krulle, T, delaFuente, C, Pickering, L, Aplin, RT, Tsitsanou, K, Zographos, SE, Oikonomakos, N, Nash, R, Griffiths, R, Fleet, G
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 1997
Diğer Bilgiler
Özet:Triazole-carboxylic acids related to D-glucose and D-galactose may be prepared by intramolecular [1,3]-dipolar cycloadditions of azides to unsaturated esters, followed by bromine oxidation of the resulting triazoline. Such materials may provide a series of anionic mimics of carbohydrates.