The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice.
The use of immunosuppressive drugs in the management of autoimmunity penalizes a large part of the immune system for the misdemeanors of a small minority of T cells. An ideal form of therapy would be one in which it were possible to render the immune system tolerant of the inciting antigens with min...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1992
|
| _version_ | 1797099659909398528 |
|---|---|
| author | Hutchings, P O'Reilly, L Parish, N Waldmann, H Cooke, A |
| author_facet | Hutchings, P O'Reilly, L Parish, N Waldmann, H Cooke, A |
| author_sort | Hutchings, P |
| collection | OXFORD |
| description | The use of immunosuppressive drugs in the management of autoimmunity penalizes a large part of the immune system for the misdemeanors of a small minority of T cells. An ideal form of therapy would be one in which it were possible to render the immune system tolerant of the inciting antigens with minimal effects on other responses. We here show that it is possible to re-establish self tolerance in an animal model of insulin-dependent diabetes mellitus without prior deletion of CD4+ T cells using a short course of therapy with a non-lytic monoclonal antibody to the CD4 adhesion receptor on T cells. This tolerance can be achieved even when diabetogenic cells are already in the pancreas. Primary responses to antigens given after therapy has ceased are normal and secondary responses to antigens seen prior to, but not during, the period of antibody therapy can remain unaffected. This suggests that intervention with selected CD4 antibodies may have significant advantages over and above that provided not only by conventional immunosuppression but also over that provided by a depleting antibody. |
| first_indexed | 2024-03-07T05:26:49Z |
| format | Journal article |
| id | oxford-uuid:e0da095a-9acf-4c09-9c3a-31314e96ea64 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:26:49Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:e0da095a-9acf-4c09-9c3a-31314e96ea642022-03-27T09:50:14ZThe use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e0da095a-9acf-4c09-9c3a-31314e96ea64EnglishSymplectic Elements at Oxford1992Hutchings, PO'Reilly, LParish, NWaldmann, HCooke, AThe use of immunosuppressive drugs in the management of autoimmunity penalizes a large part of the immune system for the misdemeanors of a small minority of T cells. An ideal form of therapy would be one in which it were possible to render the immune system tolerant of the inciting antigens with minimal effects on other responses. We here show that it is possible to re-establish self tolerance in an animal model of insulin-dependent diabetes mellitus without prior deletion of CD4+ T cells using a short course of therapy with a non-lytic monoclonal antibody to the CD4 adhesion receptor on T cells. This tolerance can be achieved even when diabetogenic cells are already in the pancreas. Primary responses to antigens given after therapy has ceased are normal and secondary responses to antigens seen prior to, but not during, the period of antibody therapy can remain unaffected. This suggests that intervention with selected CD4 antibodies may have significant advantages over and above that provided not only by conventional immunosuppression but also over that provided by a depleting antibody. |
| spellingShingle | Hutchings, P O'Reilly, L Parish, N Waldmann, H Cooke, A The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice. |
| title | The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice. |
| title_full | The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice. |
| title_fullStr | The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice. |
| title_full_unstemmed | The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice. |
| title_short | The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice. |
| title_sort | use of a non depleting anti cd4 monoclonal antibody to re establish tolerance to beta cells in nod mice |
| work_keys_str_mv | AT hutchingsp theuseofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice AT oreillyl theuseofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice AT parishn theuseofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice AT waldmannh theuseofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice AT cookea theuseofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice AT hutchingsp useofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice AT oreillyl useofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice AT parishn useofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice AT waldmannh useofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice AT cookea useofanondepletinganticd4monoclonalantibodytoreestablishtolerancetobetacellsinnodmice |