On the mechanism of base-induced rearrangements of epoxides to ketones: a formal synthesis of (S)-physoperuvine
The enantioselective α-deprotonation-rearrangement of trans- and cis-5-silyloxycycloheptene oxides (trans-8 and cis-8) using organolithiums in the presence of (-)-sparteine 16 or (-)-α-isosparteine 17 to give predominantly 4-silyloxycycloheptanone [(R)-9 (up to 87% ee), a known intermediate in the s...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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