An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth.

OBJECTIVE: In epidemiological studies, adverse early-life conditions associate with subsequent cardiometabolic disease. Hypothesized causes include maternal malnutrition, foetal glucocorticoid overexposure and reduced growth factors. Animal studies suggest a role for epigenetic processes in maintain...

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Bibliographic Details
Main Authors: Drake, A, McPherson, R, Godfrey, K, Cooper, C, Lillycrop, K, Hanson, M, Meehan, R, Seckl, JR, Reynolds, R
Format: Journal article
Language:English
Published: 2012