How ATP inhibits the open K(ATP) channel.
ATP-sensitive potassium (K(ATP)) channels are composed of four pore-forming Kir6.2 subunits and four regulatory SUR1 subunits. Binding of ATP to Kir6.2 leads to inhibition of channel activity. Because there are four subunits and thus four ATP-binding sites, four binding events are possible. ATP bind...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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