Amphiphilic 1-deoxynojirimycin derivatives through click strategies for chemical chaperoning in N370S Gaucher cells.

Míreanna comhchosúla

• Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease.
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  Foilsithe / Cruthaithe: (2012)
• Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.
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  Foilsithe / Cruthaithe: (2007)
• Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.
  de réir: Wang, G, et al.
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• Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.
  de réir: Trapero, A, et al.
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• Gaucher disease.
  de réir: Butters, T
  Foilsithe / Cruthaithe: (2007)