Amphiphilic 1-deoxynojirimycin derivatives through click strategies for chemical chaperoning in N370S Gaucher cells.

Amphiphilic 1-deoxynojirimycin derivatives through click strategies for chemical chaperoning in N370S Gaucher cells.

In Gaucher disease (GD), mutant β-glucocerebrosidases (β-GCase) that are misfolded are recognized by the quality control machinery of the endoplasmic reticulum (ER) and degraded proteolytically. Hydrophobic iminosugars can be used as pharmacological chaperones to provide an improvement in the foldin...

Podrobná bibliografie
Hlavní autoři:	Diot, J, Garcia Moreno, I, Twigg, G, Ortiz Mellet, C, Haupt, K, Butters, T, Kovensky, J, Gouin, S
Médium:	Journal article
Jazyk:	English
Vydáno:	2011

Podobné jednotky

Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease.
Autor: Wang, G, a další
Vydáno: (2012)

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.
Autor: Brumshtein, B, a další
Vydáno: (2007)

Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.
Autor: Wang, G, a další
Vydáno: (2009)

Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.
Autor: Trapero, A, a další
Vydáno: (2012)

Gaucher disease.
Autor: Butters, T
Vydáno: (2007)

Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.
Autor: Rasmussen, T, a další
Vydáno: (2011)

“Click” synthesis of amphiphilic carbohydrate-alkyl triazole derivatives
Autor: Mario Daniel Contin, a další
Vydáno: (2022-01-01)

Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins.
Autor: Mellor, H, a další
Vydáno: (2002)

Stereo-Complex and Click-Chemical Bicrosslinked Amphiphilic Network Gels with Temperature/pH Response
Autor: Wanying Yang, a další
Vydáno: (2023-08-01)

Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis.
Autor: Mellor, H, a další
Vydáno: (2004)

STUDIES ON THE MECHANISM OF ACTION OF N-BUTYL-DEOXYNOJIRIMYCIN AS AN INHIBITOR OF HIV REPLICATION
Autor: Fischer, P, a další
Vydáno: (1995)

Chaperoning glucocerebrosidase: a therapeutic strategy for both Gaucher disease and Parkinsonism
Autor: Benjamin McMahon, a další
Vydáno: (2016-01-01)

Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors.
Autor: Rawlings, A, a další
Vydáno: (2009)

Improved cellular inhibitors for glycoprotein processing alpha-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins
Autor: Alonzi, D, a další
Vydáno: (2009)

N-alkyl deoxynojirimycins as antiviral compounds.
Autor: Moriarty, R, a další
Vydáno: (2002)

Gaucher disease in North Macedonia: Unexpected prevalence of the N370S GBA1 allele with attenuated disease expression
Autor: Nevenka Ridova, a další
Vydáno: (2022-09-01)

SYNTHESIS OF DEOXYNOJIRIMYCIN AND OF NOJIRIMYCIN DELTA-LACTAM
Autor: Fleet, G, a další
Vydáno: (1990)

Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease
Autor: Kato, A, a další
Vydáno: (2016)

Small Molecule Chaperones for the Treatment of Gaucher Disease and GBA1-Associated Parkinson Disease
Autor: Tae-Un Han, a další
Vydáno: (2020-05-01)

Cellular and biochemical response to chaperone versus substrate reduction therapies in neuropathic Gaucher disease
Autor: Margarita M. Ivanova, a další
Vydáno: (2021-01-01)

Cellular and biochemical response to chaperone versus substrate reduction therapies in neuropathic Gaucher disease.
Autor: Margarita M Ivanova, a další
Vydáno: (2021-01-01)

Cellular effects of deoxynojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides.
Autor: Mellor, H, a další
Vydáno: (2004)

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery
Autor: Gamze Varan, a další
Vydáno: (2017-07-01)

α-Glucosidase inhibition of lactone intermediates of the iminosugar deoxynojirimycin
Autor: Wai Haan, Y, a další
Vydáno: (2019)

Imino sugar therapy for type 1 Gaucher disease.
Autor: Priestman, D, a další
Vydáno: (2000)

Asymmetric total synthesis of L-allo-1-deoxynojirimycin
Autor: Subhash P. Chavan, a další
Vydáno: (2015-10-01)

Gaucher Disease and Gaucher Cells
Autor: Sevgi Gözdaşoğlu
Vydáno: (2015-05-01)

An oxidation and ring contraction approach to the synthesis of (+/-)-1-deoxynojirimycin and (+/-)-1-deoxyaltronojirimycin.
Autor: Bagal, S, a další
Vydáno: (2010)

In vitro and in vivo effects of Ambroxol chaperone therapy in two Italian patients affected by neuronopathic Gaucher disease and epilepsy
Autor: Giovanni Ciana, a další
Vydáno: (2020-12-01)

Quantitative determination of 1-deoxynojirimycin in 146 varieties of mulberry fruit
Autor: Zhenjiang Wang, a další
Vydáno: (2021-01-01)

A formal total synthesis of deoxynojirimycin from D-glucitol
Autor: Braga Raquel M., a další
Vydáno: (2003-01-01)

Evaluation of the anti-hyperglycemic effect and safety of microorganism 1-deoxynojirimycin.
Autor: Soo Takasu, a další
Vydáno: (2018-01-01)

Gaucher Cells or Pseudo-Gaucher Cells: That's the Question
Autor: Deniz Gören Şahin, a další
Vydáno: (2014-12-01)

“Clicking” Amphiphilic Block Copolymers onto POSS Core: A General Approach for “Star-like” Polymers with Different Symmetry
Autor: Gang Li, a další
Vydáno: (2025-02-01)

Synthesis of Fluorinated Amphiphilic Block Copolymers Based on PEGMA, HEMA, and MMA via ATRP and CuAAC Click Chemistry
Autor: Fatime Eren Erol, a další
Vydáno: (2014-01-01)

Amphiphilic Bowl-Shaped Janus Particles Prepared via Thiol–Ene Click Reaction for Effective Oil–Water Separation
Autor: Xian Qi, a další
Vydáno: (2023-01-01)

Synthesis and Evaluation of Phenyltriazole-Deoxynojirimycin Hybrids as Potent α-Glucosidase Inhibitors
Autor: Lin Wang, a další
Vydáno: (2024-10-01)

Iminosugar 1-Deoxynojirimycin (DNJ) sebagai Antiviral Infeksi Virus Dengue
Autor: Muhammad Luthfi Adnan
Vydáno: (2020-12-01)

Effect of Ambroxol chaperone therapy on Glucosylsphingosine (Lyso-Gb1) levels in two Canadian patients with type 3 Gaucher disease
Autor: Behshad Charkhand, a další
Vydáno: (2019-09-01)

Gas-phase structure and conformation of the glycosidase and ceramide glucosyltransferase inhibitor N-benzyl deoxynojirimycin
Autor: Jockusch, R, a další
Vydáno: (2004)