Mechanisms of progression of myeloid preleukemia to transformed myeloid leukemia in children with Down syndrome

Myeloid leukemia in Down syndrome (ML-DS) clonally evolves from transient abnormal myelopoiesis (TAM), a preleukemic condition in DS newborns. To define mechanisms of leukemic transformation, we combined exome and targeted resequencing of 111 TAM and 141 ML-DS samples with functional analyses. TAM r...

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Bibliographic Details
Main Authors:	Labuhn, M, Perkins, K, Matzk, S, Varghese, L, Garnett, C, Papaemmanuil, E, Metzner, M, Kennedy, A, Amstislavskiy, V, Risch, T, Bhayadia, R, Samulowski, D, Hernandez, D, Stoilova, B, Iotchkova, V, Oppermann, U, Scheer, C, Yoshida, K, Schwarzer, A, Taub, J, Crispino, J, Weiss, M, Hayashi, A, Taga, T, Ito, E, Ogawa, S, Reinhardt, D, Yaspo, M, Campbell, P, Roberts, I, Constantinescu, S, Vyas, P, Heckl, D, Klusmann, J
Format:	Journal article
Language:	English
Published:	Elsevier 2019

Mechanisms of progression of myeloid preleukemia to transformed myeloid leukemia in children with Down syndrome

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