Mechanisms of progression of myeloid preleukemia to transformed myeloid leukemia in children with Down syndrome

Mechanisms of progression of myeloid preleukemia to transformed myeloid leukemia in children with Down syndrome

Myeloid leukemia in Down syndrome (ML-DS) clonally evolves from transient abnormal myelopoiesis (TAM), a preleukemic condition in DS newborns. To define mechanisms of leukemic transformation, we combined exome and targeted resequencing of 111 TAM and 141 ML-DS samples with functional analyses. TAM r...

书目详细资料
Main Authors:	Labuhn, M, Perkins, K, Matzk, S, Varghese, L, Garnett, C, Papaemmanuil, E, Metzner, M, Kennedy, A, Amstislavskiy, V, Risch, T, Bhayadia, R, Samulowski, D, Hernandez, D, Stoilova, B, Iotchkova, V, Oppermann, U, Scheer, C, Yoshida, K, Schwarzer, A, Taub, J, Crispino, J, Weiss, M, Hayashi, A, Taga, T, Ito, E, Ogawa, S, Reinhardt, D, Yaspo, M, Campbell, P, Roberts, I, Constantinescu, S, Vyas, P, Heckl, D, Klusmann, J
格式:	Journal article
语言:	English
出版:	Elsevier 2019

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