DNA-protein crosslink proteolysis repair
Proteins that are covalently bound to DNA constitute a specific type of DNA lesion known as DNA-protein crosslinks (DPCs). DPCs represent physical obstacles to the progression of DNA replication. If not repaired, DPCs cause stalling of DNA replication forks that consequently leads to DNA double-stra...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2017
|
| _version_ | 1826301212687859712 |
|---|---|
| author | Vaz, B Popovic, M Ramadan, K |
| author_facet | Vaz, B Popovic, M Ramadan, K |
| author_sort | Vaz, B |
| collection | OXFORD |
| description | Proteins that are covalently bound to DNA constitute a specific type of DNA lesion known as DNA-protein crosslinks (DPCs). DPCs represent physical obstacles to the progression of DNA replication. If not repaired, DPCs cause stalling of DNA replication forks that consequently leads to DNA double-strand breaks, the most cytotoxic DNA lesion. Although DPCs are common DNA lesions, the mechanism of DPC repair was unclear until now. Recent work unveiled that DPC repair is orchestrated by proteolysis performed by two distinct metalloproteases, SPARTAN in metazoans and Wss1 in yeast. This review summarizes recent discoveries on two proteases in DNA replication-coupled DPC repair and establishes DPC proteolysis repair as a separate DNA repair pathway for genome stability and protection from accelerated aging and cancer. |
| first_indexed | 2024-03-07T05:28:58Z |
| format | Journal article |
| id | oxford-uuid:e18beb37-e088-410a-ae8b-3299e1456de3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:28:58Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:e18beb37-e088-410a-ae8b-3299e1456de32022-03-27T09:55:14ZDNA-protein crosslink proteolysis repairJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e18beb37-e088-410a-ae8b-3299e1456de3EnglishSymplectic Elements at OxfordElsevier2017Vaz, BPopovic, MRamadan, KProteins that are covalently bound to DNA constitute a specific type of DNA lesion known as DNA-protein crosslinks (DPCs). DPCs represent physical obstacles to the progression of DNA replication. If not repaired, DPCs cause stalling of DNA replication forks that consequently leads to DNA double-strand breaks, the most cytotoxic DNA lesion. Although DPCs are common DNA lesions, the mechanism of DPC repair was unclear until now. Recent work unveiled that DPC repair is orchestrated by proteolysis performed by two distinct metalloproteases, SPARTAN in metazoans and Wss1 in yeast. This review summarizes recent discoveries on two proteases in DNA replication-coupled DPC repair and establishes DPC proteolysis repair as a separate DNA repair pathway for genome stability and protection from accelerated aging and cancer. |
| spellingShingle | Vaz, B Popovic, M Ramadan, K DNA-protein crosslink proteolysis repair |
| title | DNA-protein crosslink proteolysis repair |
| title_full | DNA-protein crosslink proteolysis repair |
| title_fullStr | DNA-protein crosslink proteolysis repair |
| title_full_unstemmed | DNA-protein crosslink proteolysis repair |
| title_short | DNA-protein crosslink proteolysis repair |
| title_sort | dna protein crosslink proteolysis repair |
| work_keys_str_mv | AT vazb dnaproteincrosslinkproteolysisrepair AT popovicm dnaproteincrosslinkproteolysisrepair AT ramadank dnaproteincrosslinkproteolysisrepair |