Evolution of a cycloaddition-rearrangement approach to the squalestatins: a quarter-century odyssey
The highs, lows, and diversions of a journey leading to two syntheses of 6,7-dideoxysqualestatin H5 is described. Both syntheses relied on highly diastereoselective n -alkylations of a tartrate acetonide enolate and subsequent oxidation-hydrolysis to provide an asymmetric entry to β-hydrox...
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| Médium: | Journal article |
| Jazyk: | English |
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Thieme Publishing
2020
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