Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow.
Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activi...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1826301245601611776 |
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| author | Mansour, A Abou-Ezzi, G Sitnicka, E Jacobsen, SE Wakkach, A Blin-Wakkach, C |
| author_facet | Mansour, A Abou-Ezzi, G Sitnicka, E Jacobsen, SE Wakkach, A Blin-Wakkach, C |
| author_sort | Mansour, A |
| collection | OXFORD |
| description | Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence of OCL activity resulted in a defective HSC niche associated with an increased proportion of mesenchymal progenitors but reduced osteoblastic differentiation, leading to impaired HSC homing to the BM. Restoration of OCL activity reversed the defect in HSC niche formation. Our data demonstrate that OBLs are required for establishing HSC niches and that osteoblastic development is induced by OCLs. These findings broaden our knowledge of the HSC niche formation, which is critical for understanding normal and pathological hematopoiesis. |
| first_indexed | 2024-03-07T05:29:29Z |
| format | Journal article |
| id | oxford-uuid:e1bb1ac2-ec63-42dc-ba7d-47d90a58b06d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:29:29Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:e1bb1ac2-ec63-42dc-ba7d-47d90a58b06d2022-03-27T09:56:19ZOsteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e1bb1ac2-ec63-42dc-ba7d-47d90a58b06dEnglishSymplectic Elements at Oxford2012Mansour, AAbou-Ezzi, GSitnicka, EJacobsen, SEWakkach, ABlin-Wakkach, CFormation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence of OCL activity resulted in a defective HSC niche associated with an increased proportion of mesenchymal progenitors but reduced osteoblastic differentiation, leading to impaired HSC homing to the BM. Restoration of OCL activity reversed the defect in HSC niche formation. Our data demonstrate that OBLs are required for establishing HSC niches and that osteoblastic development is induced by OCLs. These findings broaden our knowledge of the HSC niche formation, which is critical for understanding normal and pathological hematopoiesis. |
| spellingShingle | Mansour, A Abou-Ezzi, G Sitnicka, E Jacobsen, SE Wakkach, A Blin-Wakkach, C Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. |
| title | Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. |
| title_full | Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. |
| title_fullStr | Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. |
| title_full_unstemmed | Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. |
| title_short | Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. |
| title_sort | osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow |
| work_keys_str_mv | AT mansoura osteoclastspromotetheformationofhematopoieticstemcellnichesinthebonemarrow AT abouezzig osteoclastspromotetheformationofhematopoieticstemcellnichesinthebonemarrow AT sitnickae osteoclastspromotetheformationofhematopoieticstemcellnichesinthebonemarrow AT jacobsense osteoclastspromotetheformationofhematopoieticstemcellnichesinthebonemarrow AT wakkacha osteoclastspromotetheformationofhematopoieticstemcellnichesinthebonemarrow AT blinwakkachc osteoclastspromotetheformationofhematopoieticstemcellnichesinthebonemarrow |