Hydroxylation of anilides by engineered cytochrome P450BM3
Biocatalytic direct monohydroxylation of anilides has been achieved on preparative scale using mutant cytochrome P450BM3 enzymes. Representative mono- and disubstituted N-trifluoromethanesulfonyl anilides are shown to be converted in most cases to the corresponding 4-hydroxy derivatives, with substi...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Published: |
Royal Society of Chemistry
2017
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