Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.

Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.

The non-heme ferrous dependent oxidase isopenicillin N synthase (IPNS) catalyses the biosynthesis of isopenicillin N from a tripeptide substrate. The crystal structure of Aspergillus nidulans IPNS complexed to manganese reveals a six co-ordinate metal ligated by two water molecules and four protein...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Sami, M, Brown, T, Roach, P, Schofield, C, Baldwin, J
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	1997

समान संसाधन

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
द्वारा: Roach, P, और अन्य
प्रकाशित: (1995)

EXAFS STUDIES OF ISOPENICILLIN-N SYNTHASE
द्वारा: Randall, C, और अन्य
प्रकाशित: (1992)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1991)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1992)

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
द्वारा: Roach, P, और अन्य
प्रकाशित: (1997)

Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay.
द्वारा: Dubus, A, और अन्य
प्रकाशित: (2000)

FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1989)

Analysis of the conversion of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate by active-site mutants of Aspergillus nidulans isopenicillin N synthase.
द्वारा: Rowe, C, और अन्य
प्रकाशित: (1998)

GAMMA-LACTAM FORMATION FROM TRIPEPTIDES WITH ISOPENICILLIN-N SYNTHASE
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1988)

Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry.
द्वारा: Aplin, RT, और अन्य
प्रकाशित: (1990)

Modification of iron binding ligands in isopenicillin n synthase
द्वारा: Sami, M, और अन्य
प्रकाशित: (1998)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
द्वारा: Roach, P, और अन्य
प्रकाशित: (1995)

Studies on side chain interactions during the isopenicillin N synthase catalysed biosynthesis of penicillins
द्वारा: Cavelier, F, और अन्य
प्रकाशित: (1997)

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.
द्वारा: Roach, P, और अन्य
प्रकाशित: (1996)

Mechanistic studies on isopenicillin n synthase
द्वारा: Abbott, S
प्रकाशित: (1991)

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
द्वारा: Long, A, और अन्य
प्रकाशित: (2003)

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.
द्वारा: Daruzzaman, A, और अन्य
प्रकाशित: (2013)

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis
द्वारा: Rabe, P, और अन्य
प्रकाशित: (2018)

X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes.
द्वारा: Randall, C, और अन्य
प्रकाशित: (1993)

Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium.
द्वारा: Fujishima, Y, और अन्य
प्रकाशित: (1994)

Anaerobic crystallisation of an isopenicillin N synthase center dot Fe(II)center dot substrate complex demonstrated by X-ray studies
द्वारा: Roach, P, और अन्य
प्रकाशित: (1996)

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.
द्वारा: Ge, W, और अन्य
प्रकाशित: (2010)

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.
द्वारा: Long, A, और अन्य
प्रकाशित: (2005)

Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
द्वारा: Aplin, RT, और अन्य
प्रकाशित: (1993)

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.
द्वारा: Ge, W, और अन्य
प्रकाशित: (2010)

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.
द्वारा: Ge, W, और अन्य
प्रकाशित: (2009)

Photoaffinity labelling of isopenicillin N synthetase.
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1990)

Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase.
द्वारा: Nichols, C, और अन्य
प्रकाशित: (2001)

Production of functionally active <it>Penicillium chrysogenum </it>isopenicillin N synthase in the yeast <it>Hansenula polymorpha</it>
द्वारा: Veenhuis Marten, और अन्य
प्रकाशित: (2008-03-01)

Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase
द्वारा: Rabe, P, और अन्य
प्रकाशित: (2022)

Occurrence of Isopenicillin-N-Synthase Homologs in Bioluminescent Ctenophores and Implications for Coelenterazine Biosynthesis.
द्वारा: Warren R Francis, और अन्य
प्रकाशित: (2015-01-01)

Terminally truncated isopenicillin N synthase generates a dithioester product: evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidases
द्वारा: McNeill, LA, और अन्य
प्रकाशित: (2017)

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.
द्वारा: Clifton, I, और अन्य
प्रकाशित: (2011)

Mutantes letais termossensíveis em Aspergillus nidulans Temperature sensitive lethal mutants in Aspergillus nidulans
द्वारा: P. C. de Oliveira, और अन्य
प्रकाशित: (1975-01-01)

Photoaffinity labelling of isopenicillin N synthetase by laser-flash photolysis.
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1989)

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.
द्वारा: Clifton, I, और अन्य
प्रकाशित: (2011)

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.
द्वारा: Daruzzaman, A, और अन्य
प्रकाशित: (2013)

Transport Assays in Aspergillus nidulans
द्वारा: Emilia Krypotou, और अन्य
प्रकाशित: (2013-11-01)

Identification of glucose transporters in Aspergillus nidulans.
द्वारा: Thaila Fernanda Dos Reis, और अन्य
प्रकाशित: (2013-01-01)

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
द्वारा: Rabe, P, और अन्य
प्रकाशित: (2021)