Rational design of original fused-cycle selective inhibitors of tryptophan 2,3-dioxygenase

Rational design of original fused-cycle selective inhibitors of tryptophan 2,3-dioxygenase

Tryptophan 2,3-dioxygenase (TDO2) is a heme-containing enzyme constitutively expressed at high concentrations in the liver and responsible for l-tryptophan (l-Trp) homeostasis. Expression of TDO2 in cancer cells results in the inhibition of immune-mediated tumor rejection due to an enhancement of l-...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Kozlova, A, Thabault, L, Liberelle, M, Klaessens, S, Prévost, JRC, Mathieu, C, Pilotte, L, Stroobant, V, Van den Eynde, B, Frédérick, R
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	American Chemical Society 2021

Παρόμοια τεκμήρια

Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase
ανά: Kozlova, A, κ.ά.
Έκδοση: (2021)

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase
ανά: Klaessens, S, κ.ά.
Έκδοση: (2021)

Induction of tryptophan 2,3-dioxygenase expression in human monocytic leukemia/lymphoma cell lines THP-1 and U937
ανά: Hoffmann, D, κ.ά.
Έκδοση: (2019)

Inhibition of tryptophan-dioxygenase activity increases the antitumor efficacy of immune checkpoint inhibitors
ανά: Schramme, F, κ.ά.
Έκδοση: (2019)

Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual Stromal Cells Is Not Essential for Feto-Maternal Tolerance
ανά: Delia Hoffmann, κ.ά.
Έκδοση: (2020-12-01)

Tryptophan 2,3-dioxygenase expression identified in murine decidual stromal cells is not essential for feto-maternal tolerance
ανά: Hoffmann, D, κ.ά.
Έκδοση: (2020)

Systemic tryptophan homeostasis
ανά: Klaessens, S, κ.ά.
Έκδοση: (2022)

Tryptophan 2,3-dioxygenase expression identified in human hepatocellular carcinoma cells and in intratumoral pericytes of most cancers
ανά: Hoffmann, D, κ.ά.
Έκδοση: (2019)

Rational design of indoleamine 2,3-dioxygenase inhibitors.
ανά: Röhrig, U, κ.ά.
Έκδοση: (2010)

Systemic tryptophan homeostasis
ανά: Simon Klaessens, κ.ά.
Έκδοση: (2022-09-01)

Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy
ανά: Lieve Brochez, κ.ά.
Έκδοση: (2021-12-01)

Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function
ανά: Frank Elbers, κ.ά.
Έκδοση: (2016-01-01)

Unveiling the Role of Tryptophan 2,3-Dioxygenase in the Angiogenic Process
ανά: Marta Cecchi, κ.ά.
Έκδοση: (2024-04-01)

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
ανά: Solvay, M, κ.ά.
Έκδοση: (2023)

Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia.
ανά: Kudo, Y, κ.ά.
Έκδοση: (2003)

Influence of tryptophan contained in 1-Methyl-Tryptophan on antimicrobial and immunoregulatory functions of indoleamine 2,3-dioxygenase.
ανά: Silvia K Schmidt, κ.ά.
Έκδοση: (2012-01-01)

TRYPTOPHAN AND INDOLEAMINE-2,3-DIOXYGENASE (IDO) IN PATHOGENESIS OF IMMUNOSUPPRESSIVE CLINICAL CONDITIONS
ανά: V. A. Kozlov, κ.ά.
Έκδοση: (2017-07-01)

Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges
ανά: Peng X, κ.ά.
Έκδοση: (2022-08-01)

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
ανά: Luc Pilotte, κ.ά.
Έκδοση: (2023-06-01)

Indoleamine 2,3-dioxygenase-Mediated Tryptophan Catabolism Limits Experimental Abdominal Aortic Aneurysms
ανά: Baohui Xu, κ.ά.
Έκδοση: (2024-01-01)

Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation.
ανά: Kudo, Y, κ.ά.
Έκδοση: (2001)

Comprehensive behavioral analysis of tryptophan 2,3‐dioxygenase (Tdo2) knockout mice
ανά: Satoko Hattori, κ.ά.
Έκδοση: (2018-06-01)

The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
ανά: Knut A. Hestad, κ.ά.
Έκδοση: (2017-10-01)

Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia
ανά: Christine L Miller, κ.ά.
Έκδοση: (2004-04-01)

Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus
ανά: Ohira, Koji, κ.ά.
Έκδοση: (2010-09-01)

The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression
ανά: Dustin T. Nguyen, κ.ά.
Έκδοση: (2023-01-01)

Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults
ανά: Niknaz Riazati, κ.ά.
Έκδοση: (2022-09-01)

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma
ανά: Soumya R. Mohapatra, κ.ά.
Έκδοση: (2019-12-01)

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
ανά: Kanai Masaaki, κ.ά.
Έκδοση: (2009-03-01)

Fully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging
ανά: Henrottin, J, κ.ά.
Έκδοση: (2016)

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.
ανά: Orabona, C, κ.ά.
Έκδοση: (2018)

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1
ανά: Fan Liang, κ.ά.
Έκδοση: (2022-09-01)

Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells via Tryptophan 2,3 Dioxygenase
ανά: Marta Cecchi, κ.ά.
Έκδοση: (2022-06-01)

Indoleamine 2,3‐dioxygenase gene expression and kynurenine to tryptophan ratio correlation with nasopharyngeal carcinoma progression and survival
ανά: Sameh Souissi, κ.ά.
Έκδοση: (2022-09-01)

A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity in Aspergillus fumigatus–Host Interactions
ανά: Tsokyi Choera, κ.ά.
Έκδοση: (2018-01-01)

Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort
ανά: Cryan John F, κ.ά.
Έκδοση: (2009-01-01)

Acetylation of Phenylalanine Hydroxylase and Tryptophan 2,3-Dioxygenase Alters Hepatic Aromatic Amino Acid Metabolism in Weaned Piglets
ανά: Lu Huang, κ.ά.
Έκδοση: (2020-04-01)

Neopterin suppresses the activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase in human peripheral blood mononuclear cells
ανά: Schroecksnadel Sebastian, κ.ά.
Έκδοση: (2013-12-01)

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model
ανά: Xi Jiang, κ.ά.
Έκδοση: (2020-02-01)

Indoleamine 2,3 dioxygenase activity aggravates the course and pathology of murine tuberculosis
ανά: Guo, L, κ.ά.
Έκδοση: (2018)