Rational design of original fused-cycle selective inhibitors of tryptophan 2,3-dioxygenase

Rational design of original fused-cycle selective inhibitors of tryptophan 2,3-dioxygenase

Tryptophan 2,3-dioxygenase (TDO2) is a heme-containing enzyme constitutively expressed at high concentrations in the liver and responsible for l-tryptophan (l-Trp) homeostasis. Expression of TDO2 in cancer cells results in the inhibition of immune-mediated tumor rejection due to an enhancement of l-...

書誌詳細
主要な著者:	Kozlova, A, Thabault, L, Liberelle, M, Klaessens, S, Prévost, JRC, Mathieu, C, Pilotte, L, Stroobant, V, Van den Eynde, B, Frédérick, R
フォーマット:	Journal article
言語:	English
出版事項:	American Chemical Society 2021

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