C9orf72 hexanucleotide expansions are associated with altered ER calcium homeostasis and stress granule formation in iPSC-derived neurons from patients with amyotrophic lateral sclerosis and frontotemporal dementia

C9orf72 hexanucleotide expansions are associated with altered ER calcium homeostasis and stress granule formation in iPSC-derived neurons from patients with amyotrophic lateral sclerosis and frontotemporal dementia

<p>An expanded hexanucleotide repeat in a noncoding region of the <em>C9orf72</em> gene is a major cause of amyotrophic lateral sclerosis (ALS), accounting for up to 40andpercnt; of familial cases and 7andpercnt; of sporadic ALS in European populations. We have generated induced pl...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Dafinca, R, Scaber, J, Ababneh, N, Lalic, T, Weir, G, Christian, H, Vowles, J, Douglas, A, Fletcher-Jones, A, Browne, C, Nakanishi, M, Turner, M, Wade-Martins, R, Cowley, S, Talbot, K
Aineistotyyppi: Journal article
Julkaistu: Wiley 2016

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