C9orf72 hexanucleotide expansions are associated with altered ER calcium homeostasis and stress granule formation in iPSC-derived neurons from patients with amyotrophic lateral sclerosis and frontotemporal dementia
<p>An expanded hexanucleotide repeat in a noncoding region of the <em>C9orf72</em> gene is a major cause of amyotrophic lateral sclerosis (ALS), accounting for up to 40andpercnt; of familial cases and 7andpercnt; of sporadic ALS in European populations. We have generated induced pl...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Wiley
2016
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