FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.
<p>Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca<sup>2+</sup>-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating. We have therefore investigated the...
| Main Authors: | , , , , , , , |
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| 其他作者: | |
| 格式: | Journal article |
| 語言: | English |
| 出版: |
PLoS One
2012
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