Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia

There is increasing genetic evidence for the role of microglia in neurodegenerative diseases, including Alzheimer's, Parkinson's, and motor neuron disease. Therefore, there is a need to generate authentic in vitro models to study human microglial physiology. Various methods have been devel...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Washer, SJ, Perez-Alcantara, M, Chen, Y, Steer, J, James, WS, Trynka, G, Bassett, AR, Cowley, SA
Формат: Journal article
Хэл сонгох:English
Хэвлэсэн: Springer Nature 2022