P623RGS-1 modulates leukocyte trafficking in atherosclerosis and aortic aneurysm formation through chemokine receptor desensitisation.

The regulation of macrophage recruitment and retention into the vascular wall is critical in the progression of atherosclerosis and aortic aneurysm formation. This can be mediated by chemokine activation of multiple G-protein coupled receptors. The Regulator of G-Protein Signalling-1 (RGS1) acts to...

Full description

Bibliographic Details
Main Authors: Patel, J, Mcneill, E, Douglas, G, Hale, A, De Bono, J, Greaves, D, Channon, K
Format: Journal article
Language:English
Published: 2014