Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression.
Radial organization of nuclei with peripheral gene-poor chromosomes and central gene-rich chromosomes is common and could depend on the nuclear boundary as a scaffold or position marker. To test this, we studied the role of the ubiquitous nuclear envelope (NE) component lamin B1 in NE stability, chr...
| Glavni autori: | , , , , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2007
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