Assessing genuine parents-offspring trios for genetic association studies.

OBJECTIVES: Family-based association tests such as the transmission disequilibrium test (TDT) are dependent on the successful ascertainment of true nuclear family trios. Relationship misspecification inevitably occurs in a proportion of trios collected for genotyping which undetected can lead to a l...

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Bibliografische gegevens
Hoofdauteurs: Teo, Y, Fry, A, Sanjoaquin, M, Pederson, B, Small, K, Rockett, K, Kwiatkowski, D, Clark, T
Formaat: Journal article
Taal:English
Gepubliceerd in: 2009